Lab Information
Carolyn Jack (MD/PhD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Atopic dermatitis • NOD ligand • resident memory T cells • Staphylococcusaureus • T cellsResearch Interests
I am a dermatologist and PhD-trained immunologist with expertise in molecular biology, cellular immunology, immunophenotyping of primary human cells and tissues, in vitro human pre-clinical modeling of disease, and skin biospecimen-enabled clinical trials. My clinical work and research are focused on adult atopic dermatitis (AD), the most common and most burdensome skin disorder worldwide, affecting 5-10% of adults in developed countries. My research goal is to identify disease-modifying interventions in chronic AD. I have established the first Canadian disease-specific human skin and blood immunophenotyping lab, with a research program and immunophenotyping platform for investigating in situ and ex vivo mechanisms of chronic inflammation with adult AD patient skin, swabs, and blood. Patients are recruited from my specialized clinic, the Centre of Excellence for Atopic Dermatitis at the McGill University Health Centre, which is the first tertiary care centre in Canada dedicated to adult AD.Team Members
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Latest Publications
- Drucker, A. M., Zhong, Y., Tomlinson, G., Lau, K. P. L., Walwyn, C., Zhang, T., Ahad, T., Lui, H., Jack, C., Piguet, V. & Kalia, S. (2026). Narrowband vs broadband ultraviolet B phototherapy for adults with moderate-to-severe atopic dermatitis: a randomized controlled trial. The British journal of dermatology.
- Zuberbier, T., Abuzakouk, M., Angelova Fischer, I., Arruda, L. K., Augustin, M., Beck, L., Bernstein, J., Bindslev-Jensen, C., Bertolín-Colilla, M., Bangert, C., Calderón-Llosa, O., Canonica, G. W., Roldan-Castor, M. A., Casis-Hao, R. J., Cherrez-Ojeda, I., Choo, K. J. L., Chularojanamontri, L., Cork, M. J., Craig, T. J., Criado, P. R., Custovic, A., Çetinarslan, T., Çalıcıoğlu, F., de Bruin-Weller, M., Douladiris, N., Ensina, L. F., Erdem Öztürk, Y., Ertaş, R., Ferrucci, S. M., Rosário Filho, N., Flohr, C., Fluhr, J., Fomina, D., Gregoriou, S., Gotua, M., Giménez-Arnau, A. M., Hoetzenecker, W., Jack, C., Criado, R. F. J., Katoh, N., Katoulis, A., Kökçü Karadağ, Ş. İ., Larenas-Linnemann, D., Lee, H. Y., Lima, H., Mansour, E., Mortz, C. G., Morelo Rocha Felix, M., Morris, V., Moschione Castro, A., Mota Veloso Bruscky, D., Mukhina, O., Nguyen, D. V., Nosbaum, A., Ozceker, D., Özkaya, E., Oztas Kara, R., Parisi, C. A. S., Peter, J., Puig, L., Ramon, G. D., Rincón-Pérez, C., Sahiner, U. M., Schmid-Grendelmeier, P., Serra-Baldrich, E., Sevimli Dikicier, B., Smith, C. H., Staubach, P., Stevanovic, K., Su Kucuk, O., Teovska Mitrevska, N., Thaci, D., Torres, M. J., Torres, T., Trócoli Zanetti, M. E., Tuchinda, P., Vadasz, Z., Vakirlis, E., Vieira Duarte, G., Virtanen, H., Werfel, T., Wollenberg, A., Worm, M., Yew, Y. W. & Pereira, M. P. (2026). The definition of response and inadequate response to topical corticosteroid treatment in atopic dermatitis and related skin inflammatory diseases: A GA2LEN ADCARE statement paper. The World Allergy Organization journal, vol. 19, p. 101380.
- Purdy, K., Gooderham, M., Abu-Hilal, M., Armstrong, A., Asiniwasis, R., Dhadwal, G., Jack, C., Lansang, P., Lovegrove, F., Ringuet, J. & Spring, S. (2026). Supporting evidence and recommendations for the management of patients with systemic-eligible atopic dermatitis: A Canadian consensus document. JAAD international, vol. 24, p. 31-49.
- Jeremian, R., Galati, M., Fotovati, R., Li, K., Jack, C., Croitoru, D. O., Caucheteux, S., Lefrançois, P. & Piguet, V. (2025). Investigating Transcriptional Age Acceleration in Inflammatory Skin Diseases. JID innovations : skin science from molecules to population health, vol. 5, p. 100386.
- Merilleno, A. S. P., Piguet, V., Kalia, S., Walwyn, C., Lau, K. P. L., Mubaid, S., Kaur, K., Zhang, T., Ahad, T., Drucker, A. M. & Jack, C. (2025). Baseline Characteristics of the Canadian Atopic Dermatitis Cohort for Translational Immunology and Imaging. Journal of cutaneous medicine and surgery, p. 12034754251349205.
- Jeremian, R., Li, K., Galati, M., Gooderham, M., Sibbald, C., Asai, Y., Piguet, V. & Jack, C. S. (2025). DNA methylation-based analysis of leukocyte landscape in children with atopic dermatitis. Archives of dermatological research, vol. 317, p. 533.
- Jack, C. & Drucker, A. M. (2024). Fears for tears? Targeted therapies for atopic dermatitis and ocular surface health. Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 38, p. 2053-2055.
- Jeremian, R., Malinowski, A., Oh, E. S., Gooderham, M., Sibbald, C., Yeung, J., Asai, Y., Piguet, V. & Jack, C. S. (2024). Epigenetic and biological age acceleration in children with atopic dermatitis. The journal of allergy and clinical immunology. Global, vol. 3, p. 100275.
- Jeremian, R., Lytvyn, Y., Fotovati, R., Li, K., Malinowski, A., Sachdeva, M., Jack, C., Gooderham, M., Croitoru, D. O., Yeung, J. & Piguet, V. (2024). Dysregulation of epigenetic, biological and mitotic age in the context of biologic drug treatment and phototherapy in plaque psoriasis patients. Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 38, p. e883-e886.
- Asiniwasis, R., Merati, N., Roesler, J., Simpson, E. L., Aubry, R., McMullen, E., Fraess, L., Choi, U. Y., Hinther, K., Chu, D. K. & Jack, C. (2024). 'The Social and Home Environment: Impacts of Determinants of Health on Atopic Dermatitis, Pathways Towards Solutions, and Unique Considerations for Rural and Remote North American Indigenous Populations'. The journal of allergy and clinical immunology. In practice, vol. 12, p. 290-299.
