Lab Information
Bernard Turcotte (PhD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Pathogenic fungi • transcription factors • drug resistance • genome-wide analysisResearch Interests
My research focuses on functional genomics in budding yeast and the human fungal pathogen Candida glabrata. We are focusing on the Gal4 family of transcriptional regulators. The function of many of these Gal4 members is unknown or poorly defined. To better understand the role of these transcriptional regulators and identify their target genes, we are using various approaches including genetics, molecular biology and whole-genome analysis of gene expression with DNA microarrays. We are also determining the role of related Gal4 members in conferring resistance to antifungal drugs in the human pathogen Candida glabrata.Team Members
| Name | Position |
|---|
Latest Publications
- Martinez, K. P., Gasmi, N., Jeronimo, C., Klimova, N., Robert, F. & Turcotte, B. (2024). Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition. Nucleic acids research, vol. 52, p. 2242-2259.
- Turcotte, B. (2022). Editorial: Functional Genomics of Transcriptional Regulation in Pathogenic Fungi. Frontiers in cellular and infection microbiology, vol. 12, p. 928440.
- Klimova, N., Chu, S. & Turcotte, B. (2021). A lacZ reporter with high activity in the human fungal pathogen Candida albicans. FEMS yeast research, vol. 21.
- Zhang, E., Khanna, V., Dacheux, E., Namane, A., Doyen, A., Gomard, M., Turcotte, B., Jacquier, A. & Fromont-Racine, M. (2019). A specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes. The EMBO journal, vol. 38, p. e100640.
