Lab Information
Jean-Pierre Routy (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gutResearch Interests
My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.Team Members
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Latest Publications
- Ramgopal, M. N., Lalezari, J. P., Pires Dos Santos, A. G., Krishnan, P., Vaidya, T. R., Zhou, F., Betman, H., Dorr, P., Mostafa, N. M., Alcaide, M. L., Felizarta, F. & Routy, J.-P. (2025). Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study. Nature medicine.
- Xi, M., Bullock, S., Mendelsohn, J. B., Moravan, V., Burchell, A. N., Tan, D. H. S., Lebouché, B., Routy, J.-P., Daftary, A., Thompson, T. & Calzavara, L. (2025). The impact of Undetectable=Untransmittable and viral suppression on condomless sex among mixed HIV-status couples in Canada. PloS one, vol. 20, p. e0332926.
- Shegefti, S., Alaei, M., Ghahari, N., Telittchenko, R., Hanafi, S. B., Isnard, S., Routy, J.-P., Olagnier, D. & van Grevenynghe, J. (2025). Sustained inflammation during human T-lymphotropic virus type 1 infection: a wildfire contributing to disease progression. Frontiers in medicine, vol. 12, p. 1653384.
- Righetti, R., Cinque, F., Lebouché, B., Ramos Ballesteros, L., Routy, J.-P., Klein, M. B., Szabo, J., Cox, J., Falutz, J., Haraoui, L.-P., Costiniuk, C. T., De Pokomandy, A., Pembroke, T., Constante, M., Santos, M. & Sebastiani, G. (2025). Distinct Gut Microbiota Signatures Are Associated with Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease in People with HIV. International journal of molecular sciences, vol. 26.
- Giorgini, G., Silvestri, C., Mboumba Bouassa, R.-S., Muller, C., Frias Boligan, K., Kalkan, H., Routy, J.-P., Flamand, N., Di Marzo, V., Jenabian, M.-A. & Costiniuk, C. T. (2025). Impact of Oral Cannabinoids on the Endocannabinoidome and Gut Microbiome in People with HIV on Antiretroviral Therapy (CTN PT028 Pilot Clinical Trial). Cannabis and cannabinoid research.
- Margolese, S., Reinhard, R., Masching, R., Mohammadzadeh, N., Ancuta, P., Angel, J. B., Routy, J.-P., Walmsley, S., Chomont, N. & Costiniuk, C. T. (2025). Reflections upon a life well-lived: A tribute to Ron Rosenes. Journal of virus eradication, vol. 11, p. 100599.
- Ramani, H., Cleret-Buhot, A., Sylla, M., Bunet, R., Bertrand, F., Peet, M.-M., Chartrand-Lefebvre, C., Trottier, B., Thomas, R., Routy, J.-P., Fortin, C., Martel-Laferrière, V., Sadouni, M., Cloutier, G., Allard, L., Kizer, J. R., Chomont, N., Ancuta, P., Hanna, D. B., Kaplan, R. C., Jenabian, M.-A., Landay, A. L., Durand, M., El-Far, M. & Tremblay, C. L. (2025). Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV. Cells, vol. 14.
- Vulesevic, B., Lu, J., Lauscher, D., Shelton, B., Dubé, K., Routy, J.-P., Berini, C. & Costiniuk, C. T. (2025). Awareness and willingness regarding organ donation among people with HIV in Canada. AIDS care, p. 1-11.
- Nayyerabadi, M., Fourcade, L., Joshi, S. A., Chandrasekaran, P., Chakravarti, A., Massé, C., Paul, M.-L., Houle, J., Boubekeur, A. M., DuSablon, C., Boudreau, V., Bovan, D., Darbinian, E., Coleman, E. A., Vinci, S., Routy, J.-P., Hétu, P.-O., Poudrier, J. & Falcone, E. L. (2025). Corrigendum to "Vaccination after developing long COVID: Impact on clinical presentation, viral persistence and immune responses" [International Journal of Infectious Diseases, volume 136 (2023), 136-145, doi:10.1016/j.ijid.2023.09.006]. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 153, p. 107842.
- Isnard, S., Mabanga, T., Royston, L., Berini, C. A., Bu, S., Aiyana, O., Feng, H., Lebouché, B., Costiniuk, C. T., Cox, J., Kroemer, G., Durand, M., Routy, J.-P. & Biobanque Québécoise de la COVID-19 (BQC-19) (2024). Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity. Frontiers in immunology, vol. 15, p. 1505752.
See also
