Lab Information
Jean-Pierre Routy (MD)
Senior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
HIV • chronic viral infections • CMV • HHV8 • HIV reservoirs • gutResearch Interests
My research focuses on human immunodeficiency virus (HIV) pathogenesis aiming at finding an HIV cure. Improving knowledge in immune tolerance in cancer and immunometabolism will be key to developing strategy to conquer cancers and auto-immune diseases.Team Members
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Latest Publications
- Xiong, Y., Dai, B., Xiang, D., Routy, J.-P. & Zhu, B. (2025). Evolving Disease Spectrum and Characteristics of People with HIV in Eastern China: A 12-Year Study. Mediterranean journal of hematology and infectious diseases, vol. 17, p. e2025077.
- Moreira Gabriel, E., Dias, J., Filali-Mouhim, A., Caballero, R. E., Wiche Salinas, T. R., Nayrac, M., Chartrand-Lefebvre, C., Routy, J.-P., Durand, M., El-Far, M., Tremblay, C. & Ancuta, P. (2025). Alterations in Circulating T-Cell Subsets with Gut-Homing/Residency Phenotypes Associated with HIV-1 Status and Subclinical Atherosclerosis. Cells, vol. 14.
- Dos Santos, A. G. P., Abunimeh, M., Mothe, B., Routy, J.-P., Lalezari, J. P., Sinclair, G. I., Sokhela, S. M., Diaz, R. S., Schwarze, S., Berry, J., Lewin, S. R., Dubé, K., Krishnan, P., Topp, A., Gill, S. & Cohen, D. (2025). Analytical treatment interruption as a tool in the evaluation of immune-mediated interventions for long-term antiretroviral-free control of HIV-1 among people with HIV. Contemporary clinical trials, p. 108144.
- Ramgopal, M. N., Lalezari, J. P., Pires Dos Santos, A. G., Krishnan, P., Vaidya, T. R., Zhou, F., Betman, H., Dorr, P., Mostafa, N. M., Alcaide, M. L., Felizarta, F. & Routy, J.-P. (2025). Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study. Nature medicine, vol. 31, p. 3879-3888.
- Xi, M., Bullock, S., Mendelsohn, J. B., Moravan, V., Burchell, A. N., Tan, D. H. S., Lebouché, B., Routy, J.-P., Daftary, A., Thompson, T. & Calzavara, L. (2025). The impact of Undetectable=Untransmittable and viral suppression on condomless sex among mixed HIV-status couples in Canada. PloS one, vol. 20, p. e0332926.
- Shegefti, S., Alaei, M., Ghahari, N., Telittchenko, R., Hanafi, S. B., Isnard, S., Routy, J.-P., Olagnier, D. & van Grevenynghe, J. (2025). Sustained inflammation during human T-lymphotropic virus type 1 infection: a wildfire contributing to disease progression. Frontiers in medicine, vol. 12, p. 1653384.
- Righetti, R., Cinque, F., Lebouché, B., Ramos Ballesteros, L., Routy, J.-P., Klein, M. B., Szabo, J., Cox, J., Falutz, J., Haraoui, L.-P., Costiniuk, C. T., De Pokomandy, A., Pembroke, T., Constante, M., Santos, M. & Sebastiani, G. (2025). Distinct Gut Microbiota Signatures Are Associated with Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease in People with HIV. International journal of molecular sciences, vol. 26.
- Giorgini, G., Silvestri, C., Mboumba Bouassa, R.-S., Muller, C., Frias Boligan, K., Kalkan, H., Routy, J.-P., Flamand, N., Di Marzo, V., Jenabian, M.-A. & Costiniuk, C. T. (2025). Impact of Oral Cannabinoids on the Endocannabinoidome and Gut Microbiome in People with HIV on Antiretroviral Therapy (CTN PT028 Pilot Clinical Trial). Cannabis and cannabinoid research.
- Margolese, S., Reinhard, R., Masching, R., Mohammadzadeh, N., Ancuta, P., Angel, J. B., Routy, J.-P., Walmsley, S., Chomont, N. & Costiniuk, C. T. (2025). Reflections upon a life well-lived: A tribute to Ron Rosenes. Journal of virus eradication, vol. 11, p. 100599.
- Ramani, H., Cleret-Buhot, A., Sylla, M., Bunet, R., Bertrand, F., Peet, M.-M., Chartrand-Lefebvre, C., Trottier, B., Thomas, R., Routy, J.-P., Fortin, C., Martel-Laferrière, V., Sadouni, M., Cloutier, G., Allard, L., Kizer, J. R., Chomont, N., Ancuta, P., Hanna, D. B., Kaplan, R. C., Jenabian, M.-A., Landay, A. L., Durand, M., El-Far, M. & Tremblay, C. L. (2025). Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV. Cells, vol. 14.
See also
