Lab Information
Marina Klein (MD/MSc)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
http://www.cocostudy.ca/
Keywords
HIV • Hepatitis C • clinical trials • epidemiology • antiretrovirals • prospective cohortResearch Interests
My research program builds on years of multidisciplinary work leading one of the largest cohorts focused on HIV and hepatitis C virus (HCV) co-infection in the world. As Canada Research Chair in Clinical and Epidemiologic Studies of Chronic Viral Infections in Vulnerable Populations, I am documenting the impact of new HCV therapies on health outcomes, designing and testing tailored approaches to increase access to diagnosis and treatment, building capacity for research with Indigenous communities, and using evidence generated to advocate for policy change. My goal is to pave the way to eliminating HCV and other chronic viral infections in Canada and globally. To this end, I am leading an ambitious project called Montreal Sans Hep C, which aims to make Montreal the first City in North America to eliminate HCV.Team Members
Latest Publications
- Righetti, R., Cinque, F., Lebouché, B., Ramos Ballesteros, L., Routy, J.-P., Klein, M. B., Szabo, J., Cox, J., Falutz, J., Haraoui, L.-P., Costiniuk, C. T., De Pokomandy, A., Pembroke, T., Constante, M., Santos, M. & Sebastiani, G. (2025). Distinct Gut Microbiota Signatures Are Associated with Severity of Metabolic Dysfunction-Associated Steatotic Liver Disease in People with HIV. International journal of molecular sciences, vol. 26.
- Lang, R., Humes, E., Lyass, A., Borowsky, L. H., Hogan, B., Kim, A., LaValley, M., Silverberg, M. J., Kim, H. N., Napravnik, S., Moore, R. D., Horberg, M. A., Palella, F. J., Kirk, G. D., Cachay, E., Yendewa, G. A., Kassaye, S., McGinnis, K., Coburn, S. B., Sterling, T. R., Klein, M. B., Kitahata, M. M., Lesko, C., Triant, V. A. & Althoff, K. N. (2025). Direct-Acting Antiviral Initiation Among People With Hepatitis C Virus (HCV) and HIV on Antiretroviral Therapy in the United States and Canada: Factors Driving the HCV Treatment Gap. Open forum infectious diseases, vol. 12, p. ofaf454.
- Leone, P., Ferro, A., Rolle, C.-P., Lupo, S., McGowan, J., Klein, M., Cahn, P., Benson, P., Griesel, R., Warwick-Sanders, M., Sanchez, M., D'Agostino, R., Bettacchi, C., Schneider, S., Wannamaker, P., Dorey, D., Wilches, V., Gartland, M., Brown, K., Gandhi, Y., Donatti, C. & Losos, J. (2025). VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Anti-drug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results. The Journal of infectious diseases.
- Périnet, S., Williams, A., Campeau, L., Elliott, J., Zhang, F., Yang, Q., Cox, J., Davis, K., Feld, J. J., Klein, M. B., Kronfli, N., Biondi, M. J., Daley, P. K. & Popovic, N. (2025). National hepatitis B and C estimates for 2021: Measuring Canada's progress towards eliminating viral hepatitis as a public health concern. Canada communicable disease report = Releve des maladies transmissibles au Canada, vol. 51, p. 223-237.
- El Sheikh, M. Z., Young, J., Panagiotoglou, D., Cooper, C., Cox, J., Martel-Laferrière, V., Walmsley, S. & Klein, M. B. (2025). Progress Toward Hepatitis C Virus Elimination among People Living with HIV-Hepatitis C Virus Coinfection in Canada. Canadian liver journal, vol. 8, p. 49-62.
- Bédard, M., Moodie, E. E., Cox, J., Gill, J., Walmsley, S., Martel-Laferrière, V., Cooper, C. & Klein, M. B. (2025). Predicting Fatal Drug Poisoning Among People Living with HIV-HCV Co-Infection. Canadian liver journal, vol. 8, p. 295-308.
- Hammond, K., Bourdeau, F., Klein, M., Vinh, D. C. & Semret, M. (2024). Clinical Practice Guideline-Supported Administration of Monoclonal Antibody Therapy for High-Risk Patients with COVID-19: Experience of a Quaternary Care Centre. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 9, p. 140-150.
- Kronfli, N., Mambro, A., O'Brien, A., Dussault, C., Chalifoux, S., Balso, L. D., Petropoulos, A., Lim, M., Halavrezos, A., Lebouche, B., Sebastiani, G., Klein, M. B. & Cox, J. (2025). A pre-post study of the impact of a multidisciplinary model of care on linkage to hepatitis C care following release from prison: The Beyond Prison Walls study. The International journal on drug policy, vol. 143, p. 104873.
- Davy-Mendez, T., Napravnik, S., Hogan, B. C., Eron, J. J., Gebo, K. A., Althoff, K. N., Moore, R. D., Silverberg, M. J., Horberg, M. A., Gill, M. J., Colasanti, J. A., Nijhawan, A., Karris, M. Y., Klein, M. B., Lang, R., Lesko, C. R., Yendewa, G. A., Kirk, G. D., McGinnis, K. A., Berry, S. A. & North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International epidemiology Databases to Evaluate AIDS (IeDEA) (2025). Changes in the prevalence of non-AIDS conditions among hospitalized persons with HIV in the United States and Canada, 2008-2018. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Fontaine, G., Taylor, N., Bruneau, J., Kronfli, N., Greenaway, C., Biondi, M. J., Klein, M. B., Saeed, S., Grebely, J. & Presseau, J. (2025). The urgent need for implementation science to achieve hepatitis C elimination. The lancet. Gastroenterology & hepatology, vol. 10, p. 498-502.
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