Lab Information
Donald Vinh (MD)
ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Primary (genetic) immunodeficiencies • molecular genetics • translational research • immunity • infectionsResearch Interests
My research focuses on identifying how genetic defects of immunity predispose patients to infectious diseases. A fundamental enigma in the field of infectious diseases is the variability in clinical outcomes between individuals exposed to the same microbial environment. For a given microbe, what distinguishes those who are “well” or “mildly symptomatic” from those who develop “life-threatening disease”? Accumulating evidence demonstrates that mutations in critical genes can cause a variety of immunodeficiencies, resulting in human susceptibility to specific infectious diseases. My research program is distinguished by the unique ability to bring patients (and relevant family members) with unusual, severe or recalcitrant infections into the laboratory and meticulously study them, through state-of-the-art genomic and functional immunologic studies and model systems, to delineate fundamental principles of human immunobiology. In so doing, we aim to translate our findings into innovative therapies directly relevant for patients, and to discover novel diseases of human immunity.Team Members
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Latest Publications
- Fournier, M., Vanderkerken, M., Dorgham, K., Bastard, P., Ahouzi, O., Duquerroy, S., Nguyen, N. K., Broutin, M., Charlet, M., Vandenberghe, A., Van Endert, P., Bizien, L., Da Mata-Jardin, O., Ferriño-Iriarte, A., Haouz, A., Belmondo, T., Hüe, S., Borghesi, A., Rodríguez-Gallego, C., Vinh, D. C., Andreakos, E., Haerynck, F., Halwani, R., Pan-Hammarström, Q., Björkström, N. K., Strunz, B., Mogensen, T. H., COVID Human Genetic Effort, Piralla, A., Varchetta, S., Freixinet, J., Roussel, L., Trouillet Assant, S., Neven, B., Levy, R., le Voyer, T., Delmonte, O. M., O'Farrelly, C., Rivière, J., Amador Borrero, B., Servettaz, A., Kouyos, R. D., Kaufmann, D. E., Crickx, E., Michel, M., Puel, A., Abel, L., Luyt, C.-E., Mathian, A., Kisand, K., Duffy, D., Quintana-Murci, L., Amoura, Z., Hale, B. G., Weill, J.-C., Casanova, J.-L., Rey, F. A., Gorochov, G., Chappert, P. & Mahévas, M. (2026). Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections. Cell.
- Porto, L. L. T. N., Yazji, D., Unninayar, D., Decaluwe, H., Derfalvi, B., Palma, A., Issekutz, T., Kalashnikova, T., Murguía-Favela, L., Pham-Huy, A., Rubin, T., Suresh, S., Upton, J., Wright, N. A. M., Chapdelaine, H., Falcone, E. L., Top, K. A., Sadarangani, M., Vinh, D. C., Barrett, L., Oldford, S., Langlois, M.-A., Arnold, C., Zhang, T., Ramsay, T., Cowan, J. & VISID study investigators (2026). Three Doses and Six Months Later: Real-World SARS-CoV-2 Specific Humoral and Cell-Mediated Immunity in Children With Inborn Errors of Immunity. Journal of clinical immunology.
- Salmanton-García, J., Marchesi, F., Mackenzie, E., Heras-Fernando, I., Falces-Romero, I., Vena, A., Garcia-Vidal, C., Weinbergerová, B., Sgherza, N., Piukovics, K., Méndez, G. A., Leotta, D., López-García, A., Farina, F., Erben, N., Bilgin, Y. M., Biernat, M. M., Petzer, V., Magliano, G., Drgoňa, Ľ., Víšek, B., Soto-Silva, A., Samarkos, M., Navrátil, M., Lahmer, T., Fracchiolla, N. S., Vinh, D. C., Prezioso, L., Pantić, N., Khostelidi, S., Khedr, R. A., Eisa, N., Dargenio, M., Buquicchio, C., Pinczés, L. I., Papa, M. V., García-Ramírez, P., Dąbrowska-Iwanicka, A., Cuccaro, A., Čolović, N., Čerňan, M., Van Praet, J., Valković, T., Plantefeve, G., Merelli, M., Labrador, J., Kolditz, M., Glenthøj, A., Espigado, I., Erdem, S., Drozd-Sokołowska, J., Delia, M., Cerchione, C., Cattaneo, C., Batinić, J., Avendaño, A., Almasari, A., Prin, R., Nappi, D., Musto, P., Hersby, D. S., Arellano, E., Callejas-Charavia, M., Varricchio, G., Mitrović, M., Anastasopoulou, A. N., Wolf, D., Cordoba, R., Romano, A., Aiello, T. F., Bavastro, M., Limongelli, A., Giordano, A., Brunetti, S. C., Nguyen, K., Van Der Ven, L., Pagano, L. & Cornely, O. A. (2026). Underrated, Unvaccinated, Untreated: A Multinational Registry Analysis of Human Metapneumovirus in Hematological Malignancy, Insights From EPICOVIDEHA/EPIRESEHA Registry. Open forum infectious diseases, vol. 13, p. ofag099.
- Roussel, L., Bernier, S., Langelier, M., Sun, Y., Mak, B., Li, Y., Perez, A., Wloski, A., Angers, I., Vinh, L.-R., Beauchamp, A., Boissel, S., Watters, A. K., Rousseau, S., Routy, J.-P., Calderon, V., Arias, C. & Vinh, D. C. (2026). Human retinoic acid-inducible gene I (RIG-I) deficiency associated with susceptibility to classic Kaposi sarcoma. The Journal of allergy and clinical immunology.
- Lieu, A., Mah, J. K., Vinh, D. C. & Qureshi, S. T. (2026). Pulmonary Fungal Infections in the Immunocompetent Host. Chest.
- Salmanton-García, J., Marchesi, F., Navrátil, M., Falces-Romero, I., Del Principe, M. I., Labrador, J., Piukovics, K., Petzer, V., Biernat, M. M., Samarkos, M., Leotta, D., Fracchiolla, N., Dąbrowska-Iwanicka, A., Vena, A., Víšek, B., Bilgin, Y. M., Van Praet, J., Papa, M. V., Heras Fernando, I., Farina, F., Drgoňa, Ľ., Batinić, J., Weinbergerová, B., Erben, N., Drozd-Sokołowska, J., García-Ramírez, P., Cuccaro, A., Čerňan, M., Sgherza, N., Lahmer, T., Vinh, D. C., Plantefeve, G., López-García, A., Cattaneo, C., Pantić, N., Khostelidi, S., Dávila-Valls, J., Soto-Silva, A., Pinczés, L. I., Magyari, F., Khedr, R. A., Dargenio, M., Bakker, M., Stoma, I., Garcia-Vidal, C., Espigado, I., Cerchione, C., Buquicchio, C., Stojanoski, Z., Magliano, G., Gräfe, S. K., Aujayeb, A., Prezioso, L., Otašević, V., Merelli, M., Mackenzie, E., Glenthøj, A., Gavriilaki, E., Eisa, N., Delia, M., Busca, A., Almasari, A., Adžić-Vukičević, T., Urošević, I., Sili, U., Miranda-Castillo, C., Méndez, G.-A., Meers, S., Marchetti, M., Coppola, N., Çolak, G. M., Antić, D., Hersby, D. S., Musto, P., Cvetanoski, M., Schönlein, M., Aiello, T. F., Arellano, E., Nappi, D., Martín-Pérez, S., Mitrović, M., Cordoba, R., Prin, R., Callejas-Charavia, M., Varricchio, G., Bavastro, M., Limongelli, A., Anastasopoulou, A. N., Romano, A., Wolf, D., Nguyen, K., Van Den Ven, L., Di Pilla, A., Giordano, A., Cornely, O. A. & Pagano, L. (2026). Beyond the Usual Suspects: RSV Infection in Patients With Hematological Malignancies Compared to Influenza and SARS-COV-2-A Report From the EPICOVIDEHA/EPIRESEHA Registry. American journal of hematology, vol. 101, p. 365-375.
- Andreakos, E., Arkin, L., Bastard, P., Bolze, A., Borghesi, A., Brodin, P., Casanova, J.-L., Casari, G., Cobat, A., Drolet, B., Fellay, J., Hsieh, E., Meyts, I., Mogensen, T. H., Sancho-Shimizu, V., Spaan, A. N., Su, H. C., Vinh, D. C., Yatim, A., Zhang, Q., Zhang, S.-Y. & COVID Human Genetic Effort+ (2025). The seven enigmas of SARS-CoV-2: from the past to the future. Journal of human immunity, vol. 1.
- Alzahrani, R. S., Vinh, D. C., Rajda, E., Popradi, G., Dufresne, P. J. & Cheng, M. P. (2025). Disseminated Magnusiomyces clavatus (Geotrichum clavatum) infection following allogenic stem cell transplantation: a case report. ASM case reports, vol. 1.
- Chapleau, A., Le, A., Simo, J., Venkateswaran, S., Lacaze-Masmonteil, T., Piscopo, V. E. C., Gauthier, S., Villa Tobón, F., Alam, S. S., Lentini, L., Brais, B., Ernst, C., Mitchell, J. J., Vinh, D. C., Zhou, Y., Kennedy, T. E., Goloff, N., Riham, B., Chapleau, R., Smith, B., Greger, V., Della Rocca, J., Louis, L.-M., Dike, A., McIntyre, L. L., McIntyre, D. F., Tardif, J., Lapointe, É., Barnett, J., Loignon, V., Bardai, G., Contant, S., Durcan, T. M., La Piana, R., Bernard, G. & as RareKids-CAN, RARE.Qc, CARELeuko (2025). Developing a National Network for Leukodystrophy Research and Care in Canada: The CARELeuko Initiative. Neurology. Genetics, vol. 11, p. e200313.
- Bourassa, M.-H., Sillon, G., Ding, S., Chioccioli, M., Lek, M., Ma, K., Mejia-Garcia, A., Gravel, S., Vinh, D. C., Knowles, M. R., Leigh, M. W., Davis, S. D., Ferkol, T., Olivier, K. N., Schecterman, E. N., Yin, W., Sears, P. R., Gentzsch, M., Boyles, S. E., Bennett, W. D., Zeman, K. L., Ostrowski, L. E., Zariwala, M. A. & Shapiro, A. J. (2025). ODAD4-Related Primary Ciliary Dyskinesia: Report of Five Cases and a Founder Variant in Quebec. Cells, vol. 14.
See also
