Lab Information
Giada Sebastiani (MD)
Senior ScientistCentre for Outcomes Research and Evaluation
Department of Medicine (McGill)
Research Profile
Keywords
Fatty liver • serum liver biomarkers • elastography • HIV • hepatitis C • hepatitis BResearch Interests
My research focuses on screening for liver fibrosis and fatty liver of at-risk populations, including HIV+ patients, patients with diabetes and obesity, women with polycystic ovary syndrome, and patients with inflammatory bowel syndrome. To conduct these studies, I employ serum fibrosis biomarkers and a non-invasive machine, which is ultrasound-based, named Fibroscan. I am also site investigator of multiple global clinical trials for antifibrotic compounds in NASH.Team Members
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Latest Publications
- Xu, X., Shi, Y., Tacke, F., Wai-Sun Wong, V., Li, W., Sebastiani, G., Newsome, P. N., Romero-Gomez, M., Pan, C., Castera, L., Chai, J., Kim, W., Valenti, L., Yilmaz, Y., Win, K. M., Xu, X., Ocama, P., Ghazinyan, H., Al Mahtab, M., Hamid, S., Lesmana, C. R. A., Romeo, S., Castellanos Fernandez, M. I., Yu, X., Luukkonen, P. K., Takahashi, H., Charatcharoenwitthaya, P., Boursier, J., Cua, I. H., Dao, H. V., Spearman, C. W., Bandara Dassanayake, S. U., Ayurzana, M., Aghayeva, G., Muthiah, M. D., Mendez-Sanchez, N., Stedman, C. A., Alswat, K., Sharara, A. I., Debzi, N., Leite, N. C., Alkhatry, M. S., van Kleef, L. A., Barakat, S., Al-Busafi, S. A., Agyei-Nkansah, A., Fouad, Y., Gracia-Sancho, J., Lupsor-Platon, M., Ryan, J. D., Chan, W.-K., Cortez-Pinto, H., Mandorfer, M., Duseja, A., Papatheodoridis, G., Francque, S. M., Byrne, C. D., Targher, G., George, J., Zheng, M.-H., Global Hepatology Training Consortium, Xu, X., Shi, Y., Tacke, F., Wai-Sun Wong, V., Li, W., Sebastiani, G., Newsome, P. N., Romero-Gomez, M., Pan, C., Castera, L., Chai, J., Kim, W., Valenti, L., Yilmaz, Y., Win, K. M., Xu, X., Ocama, P., Ghazinyan, H., Al Mahtab, M., Hamid, S., Lesmana, C. R. A., Romeo, S., Castellanos Fernandez, M. I., Yu, X., Luukkonen, P. K., Takahashi, H., Charatcharoenwitthaya, P., Boursier, J., Cua, I. H., Dao, H. V., Spearman, C. W., Bandara Dassanayake, S. U., Ayurzana, M., Aghayeva, G., Muthiah, M. D., Mendez-Sanchez, N., Stedman, C. A., Alswat, K., Sharara, A. I., Debzi, N., Leite, N. C., Alkhatry, M. S., van Kleef, L. A., Barakat, S., Al-Busafi, S. A., Agyei-Nkansah, A., Fouad, Y., Gracia-Sancho, J., Lupsor-Platon, M., Ryan, J. D., Chan, W.-K., Cortez-Pinto, H., Mandorfer, M., Duseja, A., Papatheodoridis, G., Francque, S. M., Byrne, C. D., Targher, G., George, J., Zheng, M.-H. & Global Hepatology Training Consortium (2026). Delphi survey to explore core curriculum for training the next-generation of hepatologists☆. JHEP reports : innovation in hepatology, p. 101942.
- Abow-Mohamed, I., Alabdulkarim, B., Zhao, X., Kablawi, D., Desgagné, E., Deschenes, M., Wong, P., Chen, T., Sebastiani, G., Rehany, B., Abu-Nada, M., Valenti, D., Bessissow, A. & Benmassaoud, A. (2026). Low muscle mass predicts liver-related outcomes in cirrhosis, independent of portal hypertension: A retrospective cohort study. Canadian liver journal, vol. 9, p. 243-253.
- Zhou, X.-D., Huang, D. Q., Sebastiani, G. & Zheng, M.-H. (2026). The Changing Etiological Landscape of Liver Cancer in the Era of Metabolic Disease. Liver international : official journal of the International Association for the Study of the Liver, vol. 46, p. e70781.
- Pugliese, N., White, T. M., Brennan, P. N., Pannain, S., Hagström, H., Michel, M., Rice-Duek, L., Targher, G., Caussy, C., Dillon, J. F., Tacke, F., Kopka, C. J., Sebastiani, G., Boursier, J., Tsochatzis, E. A., Brouwer, W. P., Guaraldi, G., Vettor, R., Thiele, M., Roden, M., Stefan, N., Jarvis, H., Gines, P., Schattenberg, J. M., Pose, E., Buttigieg, S., Byrne, C. D. & Lazarus, J. V. (2026). Diagnostic innovation and models of care to improve fibrosis detection and risk stratification in steatotic liver disease. The Lancet regional health. Europe, vol. 65, p. 101722.
- White, T. M., Sebastiani, G., Guaraldi, G., Pericàs, J. M., Fuster-Ruizdeapodaca, M. J. & Lazarus, J. V. (2026). A people-first, systems-oriented approach to liver disease in HIV infection. Nature reviews. Gastroenterology & hepatology, vol. 23, p. 600-601.
- Cinque, F., Nudo, M., Saeed, S., Lim, J., Kablawi, D., Mariano, G., Lupu, A., Elgretli, W., Moodie, E. E. M., Price, C., Monteith, K., Cooper, C., Walmsley, S., Kronfli, N., Cox, J., Costiniuk, C., De Pokomandy, A., Routy, J.-P., Klein, M. B., Lebouche, B. & Sebastiani, G. (2026). Metabolic Dysfunction-Associated Steatotic Liver Disease Is Associated With Impaired Health-Related Quality of Life in People With HIV. Gastro hep advances, vol. 5, p. 100966.
- Lei, S.-Y., Han, Y., Rockey, D. C., Alswat, K., Wong, V.-W., Jumaev, N., Toro-Huamanchumo, C. J., Taha, S., El-Kassas, M., George, J., Muthiah, M., Ghanem, O., Yoneda, M., Hang, D. V., Sebastiani, G., Papatheodoridis, G., Abu-Abeid, A., Robertson, A. G., Kim, S. H., Weiner, R., Mahawar, K., Shabbir, A., Kermansaravi, M., Rajan, R., Seki, Y., Taskin, H. E., Shikora, S., Oliveros, E., Parmar, C., Cheng, Q., Thaher, O., Ruiz-Úcar, E., Oviedo, R., Ribeiro, R., Musella, M., Ramos, A. C., Ryu, S.-W., Abdelbaki, T., Lee, W. J., Chan, M. P., Garcia Flores, J. E., Skinovsky, J., Madkhali, A., Weiner, S., Tacke, F., Yang, W., Neuberger, J., Zheng, M.-H. & International Obesity Society Working Group on Steatotic Liver Disease (2026). An international multidisciplinary consensus statement on laparoscopic liver biopsy. Cell reports. Medicine, vol. 7, p. 102831.
- Farhat, R., Zamora-Medina, M. D. C., Bae, S.-C., Barber, M. R. W., Clarke, A. E., Fortin, P. R., Touma, Z., Laskin, C. A., Malhamé, I., Sebastiani, G., Peschken, C., Ugarte-Gil, M. F., Legge, A., Bernatsky, S. & Vinet, É. (2026). Increased Risk of Intrahepatic Cholestasis of Pregnancy in Women With Systemic Lupus Erythematosus Exposed to Azathioprine. Arthritis & rheumatology (Hoboken, N.J.).
- Cinque, F., Saeed, S., Farina, F., Kablawi, D., Lim, J., Cascio, A., Gioè, C., Tsochatzis, E., Lombardi, R., Cordie, A., Mohamed, R., Kamel, A. M., Esmat, G., Bandera, A., Milic, J., Benke, D., Elamouri, F., Rockstroh, J. K., Guaraldi, G. & Sebastiani, G. (2026). FIB-4 fails to identify significant liver fibrosis in people with HIV: A large multinational screening study. Hepatology (Baltimore, Md.).
- Burnside, J., Djerboua, M., Flemming, J. A., Sebastiani, G., Wong, W. W. L., Lu, Z., Bajaj, H. S., Patel, K., Biondi, M., Betel, M., Nahwegahbow, A., Greenwald, Z. R., Moodie, E. E. M. & Saeed, S. (2026). Reimbursement restrictions reduce liver fibrosis screening in adults with diabetes in Ontario: a population-based interrupted time series analysis. Scientific reports, vol. 16.
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