Lab Information

Donald Vinh (MD)

Scientist
Centre for Translational Biology
Department of Medicine (McGill)

Research Profile

 Fundamental: 75%
 Clinical: 25%
 Epidemiology: 0%
 Evaluation: 0%
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Keywords

Primary (genetic) immunodeficiencies • molecular genetics • translational research • immunity • infections

Research Interests

My research focuses on identifying how genetic defects of immunity predispose patients to infectious diseases. A fundamental enigma in the field of infectious diseases is the variability in clinical outcomes between individuals exposed to the same microbial environment. For a given microbe, what distinguishes those who are “well” or “mildly symptomatic” from those who develop “life-threatening disease”? Accumulating evidence demonstrates that mutations in critical genes can cause a variety of immunodeficiencies, resulting in human susceptibility to specific infectious diseases. My research program is distinguished by the unique ability to bring patients (and relevant family members) with unusual, severe or recalcitrant infections into the laboratory and meticulously study them, through state-of-the-art genomic and functional immunologic studies and model systems, to delineate fundamental principles of human immunobiology. In so doing, we aim to translate our findings into innovative therapies directly relevant for patients, and to discover novel diseases of human immunity.


Team Members

Name Position

Latest Publications

  1. Vinh, D. C. (2024). From Mendel to mycoses: Immuno-genomic warfare at the human-fungus interface. Immunological reviews, vol. 322, p. 28-52.
  2. Mohammed, Y., Tran, K., Carlsten, C., Ryerson, C., Wong, A., Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Murthy, S., Jain, F., Borchers, C. H., Goodlett, D. R., Levin, A., Russell, J. A. & ARBs CORONA I Consortium (2024). Proteomic Evolution from Acute to Post-COVID-19 Conditions. Journal of proteome research, vol. 23, p. 52-70.
  3. Roussel, L., Pham-Huy, A., Yu, A. C., Venkateswaran, S., Perez, A., Bourdel, G., Sun, Y., Villavicencio, S. T., Bernier, S., Li, Y., Kazimerczak-Brunet, M., Alattar, R., Déry, M.-A., Shapiro, A. J., Penner, J. & Vinh, D. C. (2023). A Novel Homozygous Mutation Causing Complete TYK2 Deficiency, with Severe Respiratory Viral Infections, EBV-Driven Lymphoma, and Jamestown Canyon Viral Encephalitis. Journal of clinical immunology, vol. 43, p. 2011-2021.
  4. Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D. M., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Russell, J. A. & for ARBs CORONA I (2023). Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave. CMAJ open, vol. 11, p. E672-E683.
  5. Giralt, S., Jolles, S., Kerre, T., Lazarus, H. M., Mustafa, S. S., Papanicolaou, G. A., Ria, R., Vinh, D. C. & Wingard, J. R. (2023). Recommendations for Management of Secondary Antibody Deficiency in Multiple Myeloma. Clinical lymphoma, myeloma & leukemia, vol. 23, p. 719-732.
  6. Alemayehu, T. & Vinh, D. C. (2023). A Novel Mutation Leading to Wiskott-Aldrich Syndrome in an Ethiopian Boy: a Case Report and a Review of Literature. Journal of clinical immunology, vol. 43, p. 1272-1277.
  7. Saginur, R., Robblee, J. A., Vranjkovic, A., Tamblyn, L., Hsu, A., Cooper, C. L., Vinh, D. C., Langlois, M.-A. & Crawley, A. M. (2023). No time for complacency: The CoVaRR-Net Biobank is an essential element of laboratory preparedness for infectious disease outbreaks. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 8, p. 75-84.
  8. Vinh, D. C. (2023). Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases. Pathogens (Basel, Switzerland), vol. 12.
  9. Olbrich, P. & Vinh, D. C. (2023). Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases. Journal of fungi (Basel, Switzerland), vol. 9.
  10. Jolles, S., Giralt, S., Kerre, T., Lazarus, H. M., Mustafa, S. S., Ria, R. & Vinh, D. C. (2023). Agents contributing to secondary immunodeficiency development in patients with multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin lymphoma: A systematic literature review. Frontiers in oncology, vol. 13, p. 1098326.
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