Lab Information
Matthew Cheng (MD)
Junior ScientistCentre for Translational Biology
Department of Medicine (McGill)
Research Profile
Keywords
Lethal infectious diseases • opportunistic infections • sepsis • bacteremiaResearch Interests
My research focuses on patients with potentially lethal infections, including those with severe manifestations of sepsis, bloodstream infections, and opportunistic infections in immunocompromised hosts. My research program aims to improve morbidity and mortality in these conditions by discovering original treatment strategies through avant-garde clinical trials. I also develop novel diagnostic assays to improve outcomes in these patients, such as using plasma cell-free DNA to monitor the host response to infection and optimize treatment decisions.Team Members
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Latest Publications
- Le, M., Khoury, L., Lu, Y., Prosty, C., Cormier, M., Cheng, M. P., Fowler, R., Murthy, S., Tsang, J. L. Y., Ben-Shoshan, M., Rahme, E., Golchi, S., Dendukuri, N., Lee, T. C. & Netchiporouk, E. (2024). COVID-19 Immunologic Antiviral Therapy With Omalizumab (CIAO)-a Randomized Controlled Clinical Trial. Open forum infectious diseases, vol. 11, p. ofae102.
- Lee, C. H., Banoei, M. M., Ansari, M., Cheng, M. P., Lamontagne, F., Griesdale, D., Lasry, D. E., Demir, K., Dhingra, V., Tran, K. C., Lee, T., Burns, K., Sweet, D., Marshall, J., Slutsky, A., Murthy, S., Singer, J., Patrick, D. M., Lee, T. C., Boyd, J. H., Walley, K. R., Fowler, R., Haljan, G., Vinh, D. C., Mcgeer, A., Maslove, D., Mann, P., Donohoe, K., Hernandez, G., Rocheleau, G., Trahtemberg, U., Kumar, A., Lou, M., Dos Santos, C., Baker, A., Russell, J. A., Winston, B. W. & *ARBs CORONA I. Investigators (2024). Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia. Critical care (London, England), vol. 28, p. 63.
- Lieu, A., Harrison, L. B., Harel, J., Lawandi, A., Cheng, M. P. & Domingo, M.--. C. (2024). The microbiological outcomes of culture-negative blood specimens using 16S rRNA broad-range PCR sequencing: a retrospective study in a Canadian province from 2018 to 2022. Journal of clinical microbiology, vol. 62, p. e0151823.
- Prosty, C., Katergi, K., Nguyen, A., Luo, O. D., Sorin, M., Cherniak, V., Sebag, M., Demir, K., McDonald, E. G., Lee, T. C. & Cheng, M. P. (2024). Infectious Complications of Venetoclax Treatment of Hematologic Malignancies: A Systematic Review and Meta-Analysis. Blood advances, vol. 8, p. 857-866.
- Mohammed, Y., Tran, K., Carlsten, C., Ryerson, C., Wong, A., Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D., Singer, J., Patrick, D. M., Marshall, J. C., Murthy, S., Jain, F., Borchers, C. H., Goodlett, D. R., Levin, A., Russell, J. A. & ARBs CORONA I Consortium (2024). Proteomic Evolution from Acute to Post-COVID-19 Conditions. Journal of proteome research, vol. 23, p. 52-70.
- de Kretser, D., Mora, J., Bloomfield, M., Campbell, A., Cheng, M. P., Guy, S., Hensgens, M., Kalimuddin, S., Lee, T. C., Legg, A., Mahar, R. K., Marks, M., Marsh, J., McGlothlin, A., Morpeth, S. C., Sud, A., Ten Oever, J., Yahav, D., Tong, S. Y., Davis, J. S., Walls, G., Goodman, A. L., Bonten, M. & Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group members (2023). Early oral antibiotic switch in Staphylococcus aureus bacteraemia: The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Early Oral Switch Protocol. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
- Lieu, A., Lee, T. C., Lawandi, A., Tellier, R., Cheng, M. P. & Dufresne, P. J. (2023). Microbiological characterization of Pneumocystis jirovecii pneumonia using quantitative PCR from nasopharyngeal specimens: a retrospective study in a Canadian province from 2019 to 2023. Journal of clinical microbiology, p. e0091323.
- Camirand Lemyre, F., Honfo, S. H., Caya, C., Cheng, M. P., Colwill, K., Corsini, R., Gingras, A.-C., Jassem, A., Krajden, M., Márquez, A. C., Mazer, B. D., McLennan, M., Renaud, C., Yansouni, C. P., Papenburg, J. & Lewin, A. (2023). Two-phase Bayesian latent class analysis to assess diagnostic test performance in the absence of a gold standard: COVID-19 serological assays as a proof of concept. Vox sanguinis, vol. 118, p. 1069-1077.
- Lee, T., Cheng, M. P., Vinh, D. C., Lee, T. C., Tran, K. C., Winston, B. W., Sweet, D., Boyd, J. H., Walley, K. R., Haljan, G., McGeer, A., Lamontagne, F., Fowler, R., Maslove, D. M., Singer, J., Patrick, D. M., Marshall, J. C., Burns, K. D., Murthy, S., Mann, P. K., Hernandez, G., Donohoe, K., Russell, J. A. & for ARBs CORONA I (2023). Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave. CMAJ open, vol. 11, p. E672-E683.
- Cheng, M. P., Paquette, K., Lawandi, A., Stabler, S. N., Akhter, M., Davidson, A. C., Gavric, M., Jinah, R., Saeed, Z., Demir, K., Sangsari, S., Huang, K., Mahpour, A., Shamatutu, C., Caya, C., Troquet, J.-M., Clark, G., Rush, B., Wong, T., Stenstrom, R., Sweet, D. & Yansouni, C. P. (2022). qSOFA does not predict bacteremia in patients with severe manifestations of sepsis. Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada, vol. 7, p. 364-368.
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